At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary
We are seeking a Clinical Systems Architect with strong Architecture and DevOps expertise to serve as a technical bridge between application development and IT infrastructure teams. This role requires deep knowledge of CI/CD pipelines, information security, networking, and cloud operations, while maintaining strong full-stack development capabilities. The ideal candidate will collaborate with Software Engineers, Architects, Engineering Managers, Product Managers, and IT teams to deliver secure, scalable, and high-availability solutions.

Job Responsibilities

• Lead the design and implementation of CI/CD pipelines with automated deployment strategies, SAST/DAST scanning, and infrastructure as code

• Architect and maintain cloud-native solutions across AWS, GCP, or Azure, ensuring optimal performance and cost efficiency

• Implement and manage security guardrails including authentication mechanisms, encryption protocols, and compliance frameworks (HIPAA, OIDC/OAuth 2.0)

• Design and optimize networking solutions for high-availability, load balancing, and secure data transmission

• Develop full-stack applications using Python and/or Node.js/Next.js with Vue.js or React

• Integrate with monitoring and observability tools (Sentry, Datadog, NewRelic, Grafana) for comprehensive application performance management

• Implement containerization strategies using Docker and Kubernetes for scalable deployments

• Design and maintain RESTful APIs with security-first principles

• Serve as the primary liaison between application development and IT teams (Networking, InfoSec, Cloud Operations)

• Automate infrastructure provisioning and deployment processes using DevOps methodologies

• Implement security scanning and monitoring throughout the development lifecycle

• Collaborate with cloud operations teams to ensure seamless releases and incident response

• Monitor incident tickets and determine resolution priority

• Perform code reviews and offer constructive feedback

• Provide technical/engineering support for existing applications, including code fixes

• Analyze and solve complex technical problems, ensuring code quality, performance, and scalability

• Collaborate with other departments (product management, quality assurance) for seamless product delivery

• Assist management with timelines, resource estimates, and delivery details

• Mentor and coach junior developers

• Perform other related duties as assigned

Required Qualifications

• Bachelor's degree in Computer Science, Software Engineering, or related field

• 5-7 years of DevOps & Infrastructure experience including expert-level proficiency in CI/CD methodologies and pipeline automation

• 5-7 years of Programming & Development experience with advanced Python programming and JavaScript/TypeScript expertise including Node.js, Vue.js, or React

• Strong experience with containerization (Docker, Kubernetes preferred)

• Proven track record in cloud architecture (AWS Lambda, SNS/SQS, S3, or equivalent GCP/Azure services)

• Comprehensive understanding of networking principles and security protocols

• Database design and optimization (MySQL, PostgreSQL, ORM technologies)

• API design and security implementation (REST, authentication, encryption)

• Deep knowledge of information security best practices and implementation

• Experience with security scanning tools (SAST/DAST) and vulnerability management

• Understanding of compliance frameworks (HIPAA, SOC 2, etc.)

• Proficiency in implementing security protocols (OIDC/OAuth 2.0, encryption)

• Version control systems (Git) and collaborative development workflows

• Monitoring and alerting platforms (Grafana, Sentry, Datadog, NewRelic)

• Infrastructure automation and configuration management

• Performance optimization and scalability planning

• Excellent problem-solving skills, analytical thinking, strong communication skills, and ability to work collaboratively in team-oriented environments

Preferred Qualifications

• Experience with AI-assisted development tools (Cursor AI)

• Advanced networking and security certifications (CISSP, CCNA, AWS Security)

• Experience with service mesh technologies and microservices architecture

• Knowledge of data pipeline architecture and ETL processes

• Experience with incident response and disaster recovery planning

• Demonstrated capability to independently diagnose, analyze, and resolve complex issues related to application software

• Skilled in ensuring HIPAA compliance, improving patient outcomes, and maintaining quality assurance standards while adhering to regulatory requirements

Physical Demands

• Ability to sit, stand, and work at a computer for extended periods

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Training

• All job-specific, safety, and compliance training assigned based on job functions

Other

• This position requires periodic travel and flexible availability, including some evenings, weekends, and/or holidays.

• The role may require after-hours response to emergency issues. There are also occasionally scheduled on-call duties that necessitate responding to technical emergencies beyond assigned job responsibilities.

Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.