At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary

The Senior Medical Director for Multi-Cancer Early Detection (MCED) will serve as a senior physician-executive leader responsible for guiding the medical, scientific, and clinical strategy for Caris’ rapidly evolving MCED portfolio. This role provides high-impact medical leadership across clinical development, product innovation, evidence generation, regulatory strategy, and external scientific engagement.

The ideal candidate is a nationally recognized physician with substantial experience in oncology, cancer screening, early detection methodologies, and/or molecular diagnostics. This leader will ensure Caris’ MCED initiatives are clinically rigorous, patient-centric, and aligned with emerging scientific and regulatory standards. They will collaborate extensively with internal teams—including R&D, Clinical Development, Regulatory, Commercial, and Medical Affairs—as well as external stakeholders, KOLs, investigators, and regulatory bodies.

This is a high-visibility role for an executive with deep clinical insight, strategic vision, and exceptional communication and public-facing skills.

Job Responsibilities

• Provide medical, scientific, and clinical expertise for MCED strategy, clinical protocols, regulatory submissions, and study design.

• Serve as the principal internal medical authority for MCED programs, ensuring scientific rigor and alignment with corporate objectives.

• Interpret and communicate clinical and analytical performance data, including safety, efficacy, and real-world evidence.

• Oversee development of scientific publications, abstracts, peer-reviewed manuscripts, and presentations.

• Partner cross-functionally with Regulatory, Clinical Operations, Biostatistics, R&D, Product, Market Access, and Commercial teams to ensure seamless program execution and clinical relevance.

• Engage and cultivate relationships with external experts, investigators, clinical partners, advocacy groups, and regulatory agencies.

• Act as the lead internal physician representing the clinical user experience and real-world clinical workflows for Caris’ MCED products.

• Represent Caris at national and international scientific meetings, advisory boards, and industry forums.

• Monitor emerging trends in oncology, early detection, liquid biopsy, genomics, biomarkers, and relevant clinical practice guidelines to inform strategy and innovation.

Required Qualifications

• MD (or equivalent) with board certification in oncology, hematology, clinical pathology, or a related specialty.

• ≥5 years of direct patient care experience, ideally in oncology or a related field with exposure to cancer screening and diagnostic pathways.

• ≥5 years of experience in clinical development or product development, ideally within oncology diagnostics, screening, or early detection technologies.

• Demonstrated expertise in biomarker-driven oncology, molecular diagnostics, cancer screening methodologies, or liquid biopsy platforms.

• Strong understanding of clinical trial design, evidence generation, and regulatory considerations for diagnostic products.

• Outstanding written and verbal communication skills, with experience presenting to scientific, clinical, and executive audiences.

• Proven ability to lead in a fast-paced, matrixed environment while managing multiple priorities.

• Familiarity with health economics, outcomes research, and real-world evidence generation relevant to diagnostic adoption.

Preferred Qualifications

• Direct experience interacting with regulatory authorities (e.g., FDA, EMA) with successful contributions to submissions for diagnostic or screening technologies.

• Prior leadership experience in industry within diagnostics, biotech, or medtech with focus on oncology or early detection.

• Established network among oncology KOLs, screening experts, pathology leaders, and/or clinical investigators.

Physical Demands

• Ability to sit or stand for extended periods.

• Ability to perform repetitive motions.

• Ability to lift up to 25 pounds.

Training

• All required job-specific, safety, and compliance training will be assigned based on job functions.

Other Requirements

• This role requires frequent travel to scientific conferences, investigator meetings, customer engagements, and internal leadership meetings.

• Some evening, weekend, and holiday availability may be required.

Annual Hiring Range

$340,000 - $400,000

Actual compensation offer to candidate may vary from posted hiring range based upon geographic location, work experience, education, and/or skill level. The pay ratio between base pay and target incentive (if applicable) will be finalized at offer.

Description of Benefits

• Highly competitive and inclusive medical, dental and vision coverage options

• Health Savings Account for medical expenses and dependent care expenses

• Flexible Spending Account to pay for certain out-of-pocket expenses

• Paid time off, including: vacation, sick time and holidays

• 401k match and Financial Planning tools

• LTD and STD insurance coverages, as well as voluntary benefit options

• Employee Assistance Program

• Pet Insurance

• Legal Assistance

• Tuition Assistance

Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.