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Senior Mechanical Engineer

DNA Script

DNA Script

le kremlin-bicêtre, france
Posted on Tuesday, March 26, 2024

DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in Daly City.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a dynamic company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The Role

  • Design, develop, test, and industrialize mechatronics subsystems for life science instrumentation;

Main Responsibilities

  • From the concept phase to commercialization, design, develop, test, and integrate mechatronic subsystems for multi-axis liquid handling automation platforms, to enable on-demand DNA printing through enzymatic DNA synthesis (EDS).
  • Define subsystem requirements to meet functional and regulatory requirements and expected performance at the system level;
  • Perform failure analysis of complex electro-mechanical assemblies, identifying root causes and corrective actions;
  • Conduct multiphysics simulation (structural, fluidic, thermal);
  • Create detailed engineering drawings, Bills of Materials (BOM), test reports, assembly procedures, and design validation plans;
  • Ensure integrity of the technical repository (CAD and BOM) and Product Lifecycle Management (PLM) at the system level;
  • Define IVV (Integration, Verification, and Validation) protocols for the subsystems;
  • Identify, manage and coordinate suppliers or subcontractors;
  • Successfully transition designs from concept to production;
  • Collaborate with multidisciplinary engineering resources (Software engineers, Electronic & Electrical engineers, Chemistry & Biochemistry scientists).

Qualifications and Education Requirements

  • or MSc. in Mechanical Engineering, Mechatronics, Robotics or other relevant field;
  • 5+ years of experience in mechanical engineering, including mechatronics, and/or high-precision automation, and/or robotics;
  • Solid grasp of engineering fundamentals (mechanical engineering, material science, motion control systems, fluid mechanics, heat transfer);
  • Experience with 3D solid modeling and 2D drawing creation (Solidworks preferred);
  • Proficient demonstration of GD&T;
  • Hands-on experience with 3D printing and prototyping;
  • Hands-on experience producing design documentation, in support of releasing new products into manufacturing.

Preferred Skills and Abilities

  • Experience in life science instrumentation is a plus;
  • Experience in the development of laboratory automation systems is a significant plus;
  • Experience with regulated device product development a plus.


  • Job located in Le Kremlin-Bicêtre, France;
  • Start date: As soon as possible;

Recruitment Process

  • Initial screening with the hiring manager;
  • Day interview at the office (or remote) with the manager, cofounders, HR and the rest of the team;
  • Reference Checks;
  • Timing: 2-3 weeks.