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Director, Biochemistry Research

DNA Script

DNA Script

le kremlin-bicêtre, france
Posted on Wednesday, June 26, 2024

DNA Script

DNA Script is a leading company in the production of nucleic acids for genomic, synthetic biology and biopharmaceutical applications.

Our clean, efficient Enzymatic DNA Synthesis (EDS) technology, implemented on a benchtop instrument (the SYNTAX), accelerates innovation in life science and biotechnology through the decentralization of rapid, on demand and high quality DNA synthesis.

Our approach builds upon nature's billions of years of evolution in enzymatically synthesizing DNA, setting new standards for assembling nucleic acids to accelerate scientific discovery and DNA/RNA production in disciplines with profound impacts upon humanity.

DNA Script has a broad stable of high quality investors and is capitalized to continue its progress to full commercialization of the technology and products. We are building an organization across our two sites, in Paris and San Francisco, with the talent, skills and attitude to achieve our mission: to unlock the power of “DNA-write”.

This is an opportunity for a dynamic individual to join an international and highly skilled team, and to make significant contributions to commercializing a technology with far-reaching potential across the biological sciences and beyond.

The role

The Director of Biochemistry Research will lead the R&D team in charge of enhancing our Enzymatic DNA Synthesis technology and particularly its’ biochemical components. That scope includes:

  • Enzyme engineering to improve the performances of our enzymes
  • Modified nucleotides chemistry including labeling technology, reversible terminatorsand associated deprotection reagents
  • New materials and surface chemistry for the development of Innovative solid supports for DNA synthesis

We are looking for a scientific leader with expertise in the field, ability to drive scientific projects, suggest new ideas, as well as to manage a team of 11 scientists, engineers and technicians. You will have a unique opportunity to impact the way DNA is synthesized by pushing its performances through new, optimized reagents and bring a strong contribution to molecular biology.

This role requires strong communication, interpersonal and organizational skills and a solid scientific background in related fields such as sequencing by synthesis..

The Director, Biochemistry Research role is based in Kremlin-Bicêtre (South of Paris) and reports to the Chief Technology Officer. You will work in close relationship with the Director, Protocol Research who is in charge of optimizing synthesis protocols on dedicated hardware.

Responsibilities

  • Lead and manage the Biochemistry Research team, which includes Enzyme Engineering, Nucleotide, Chemistry, CMOS Synthesis and Solid Support Development,
  • Manage the team’s budget,
  • Create team objectives and ensure progress towards those objectives,
  • Lead scientific projects, provide creative ideas, do bibliography, ensure good technical communication within the team,
  • Interpret provided data from the team and act based on said data.
  • Coach team members to help them grow in their professional abilities and skills,
  • Become an expert in the Enzymatic DNA Synthesis field, keeping track of competition progress, and adapting internal work to the ecosystem,
  • Contribute to the R&D strategy and operation,
  • Collaborate with other R&D leaders and other departments (Operations, Commercial, etc)
  • Create Intellectual Property,
  • Manage relationship with external academic partners, suppliers, collaborators, grant agencies,
  • Perform other duties as assigned.

Qualifications and experience

Essential

  • PhD preferred life science e.g. Chemistry, Molecular Biology, Genomics, Biotechnology or similar,
  • 10+ years of experience as a Scientist or manager in Chemistry, Molecular Biology, Genomics or similar,
  • Proven experience interacting with external collaborators
  • Detailed technical orientation, with robust analytical and organization skills, problem solving, troubleshooting capabilities, and negotiation skills
  • Project and or team management, including managing several projects in parallel with tight deadline,
  • Demonstrated scientific leadership, high organizational and prioritization skills
  • Excellent written and verbal communication skills in English, presentation skills and technical aptitude

Desirable

  • Experience in nucleic acid chemistry and biochemistry, analysis, nucleotide chemistry, or DNA synthesis
  • Excellent knowledge of analytical methods for nucleotides and nucleic acids, in particular NGS data interpreting
  • Experience in managing international project/collaboration/consortium under government research funding programs
  • Strong track record of writing of scientific publications, patent applications
  • Programming in R, Python, C/C++ or MATLAB is a plus
  • Start-up mindset.

Miscellaneous

  • Job located in Le Kremlin Bicêtre (Paris area)
  • Start date: As soon as possible.

Recruitment Process:

  • Initial screening with the hiring manager
  • Day interview at the office (or remote) with the manager, cofounders, HR and the rest of the team
  • Reference Checks
  • Timing: 2-3 weeks