Engineer, Enzyme Engineering
DNA Script
DNA Script
DNA Script is a leading company in the production of nucleic acids for genomic, synthetic biology and biopharmaceutical applications.
Our clean, efficient Enzymatic DNA Synthesis (EDS) technology, implemented on a benchtop instrument (the SYNTAX), accelerates innovation in life science and biotechnology through the decentralization of rapid, on demand and high quality DNA synthesis.
Our approach builds upon nature's billions of years of evolution in enzymatically synthesizing DNA, setting new standards for assembling nucleic acids to accelerate scientific discovery and DNA/RNA production in disciplines with profound impacts upon humanity.
DNA Script has a broad stable of high quality investors and is capitalized to continue its progress to full commercialization of the technology and products. We are building an organization across our two sites, in Paris and San Francisco, with the talent, skills and attitude to achieve our mission: to unlock the power of “DNA-write”.
This is an opportunity for a dynamic individual to join an international and highly skilled team, and to make significant contributions to commercializing a technology with far-reaching potential across the biological sciences and beyond.
The Role
DNA Script is looking for a highly motivated, well-organized team-player to join the Enzyme Engineering team as an Engineer. Your role will be to help us discover and evolve our proprietary DNA polymerase variants (TdT) for DNA synthesis technology.
You will be involved in different steps of enzyme variant screening: (i) mutant expression and purification, (ii) sequencing, (iii) mutants characterization (automated DNA synthesis, stability, …), (iv) presentation of results and reporting.
The Enzyme Engineering team comprises two people: Research Assistant and Team leader (PhD), and is part of the Reagent Research team (12 people).
Main Responsibilities:
- Express, purify and prepare enzyme variants at small scale
- Prepare and perform automated runs to test purified enzyme variants in automated DNA synthesis run
- Run efficiently and reproducibly day to day operations
- Perform data analysis and generate meaningful insights from complex data sets
- Optimize screening procedures
- Interact with research (chemistry, analytics, innovation) and synthesis teams
- Engagement in good laboratory and good documentation practices
- Support the team when needed
Experience:
Essential:
- Master’s or Engineering Degree in Biochemistry, Biotechnology or Biology
- ≥ 2 years’ experience in private company or public institute
- ‘Hands on’ working experience in biochemistry lab
- Familiarity with protein handling, expression and purification
- Good skills in data analysis and data visualization
- Strong record keeping skills, organization and rigor
- Strong interpersonal skills
- Good command of the English language
Desirable
- Experience in automation (Hamilton)
- Coding skills (Python)
- Experience in NGS data
- Experience in enzymology
Miscellaneous:
- Job located in Kremlin-Bicêtre, France
- Start date: 01 January or sooner
Recruitment Process:
- Initial screening with the hiring manager
- Day interview at the office with the manager, HR and the rest of the team
- Reference Checks
- Timing: 2-3 weeks