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Research Scientist I/II Computational

Entos

Entos

San Diego, CA, USA
Posted on Saturday, June 22, 2024

JOB SUMMARY

We are seeking a motivated computational chemist to join our team in San Diego. This role is based on site at our San Diego headquarters. As part of a multi-disciplinary team you will be engaged in drug discovery projects, both applying structure-based drug design as well as integrating new AI technologies in the drug discovery process. This role forms part of a group of computational scientists at Iambic who will collaborate closely with cross-functional teams to drive projects from target identification through preclinical development.

KEY RESPONSIBILITIES

  • Leverage computational approaches in structure-based drug discovery, and our use of a wide range of computational tools for all aspects of preclinical drug discovery.
  • Collaborate with medicinal chemists, biologists, machine learning scientists and other stakeholders on all aspects of preclinical drug discovery.
  • Apply molecular dynamics to simulate protein flexibility to allow high-accuracy prediction of binding site, binding mode, and binding kinetics of small molecules to proteins.
  • Investigate, explore and utilize state-of-the-art AI methods for molecular discovery.

QUALIFICATIONS

  • Ph.D. in chemistry or related field with 0-5 years industry experience in drug discovery.
  • For candidates with industrial experience: Proven track record of small-molecule drug design with significant impact on drug discovery projects.
  • Demonstrated ability to apply computational techniques to solve complex challenges in protein function and/or small-molecule drug discovery.

ABOUT IAMBIC THERAPEUTICS

Iambic Therapeutics is disrupting the therapeutics landscape with its cutting-edge generative AI drug discovery platform. We have assembled a world-class team that unites pioneering AI experts and seasoned drug hunters with strong track records of success in delivering clinically validated breakthrough treatments. The Iambic Therapeutics platform has been demonstrated to deliver high quality, differentiated drugs to clinic with unprecedented speed and across multiple target classes and mechanisms of action. We are focused on the advancement on our internal pipeline of clinical assets to address urgent unmet patient need in oncology and other therapeutic areas.

MISSION & CORE VALUES

The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

PAY AND BENEFITS

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.